Growth factor/growth factor receptor loops in autocrine growth regulation of human prostate cancer DU145 cells.
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چکیده
منابع مشابه
Growth factor/growth factor receptor loops in autocrine growth regulation of human prostate cancer DU145 cells.
Autocrine growth factors produced by epithelial cells mediate the development and proliferation of neoplastic human prostate tissue. Various approaches have been used to down-regulate neoplastic growth of prostate cancer using natural flavonoids, soluble receptors, pseudo-ligands, monoclonal antibodies and tyrosine kinase inhibitors (tyrphostins). Selected growth factor/growth factor receptor l...
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It is well established that autocrine growth of human prostate cancer cell line DU145 is dependent on TGF (EGF)/EGFR loop. However, the participation of several other growth factors in proliferation of DU145 cells has been also proposed. We employed two selective tyrosine kinase inhibitors (tyrphostins): AG1024 (an IGFIR inhibitor) and SU1498 (a VEGFR2 inhibitor) for growth regulation of DU145 ...
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ژورنال
عنوان ژورنال: Acta Biochimica Polonica
سال: 2011
ISSN: 1734-154X,0001-527X
DOI: 10.18388/abp.2011_2252